Medicine
Thu Aug 06, 2020 2:47
Anti-Aging Drug Targets Alzheimer's by Altering Metabolism in Brain
TEHRAN (FNA)- Scientists investigating Alzheimer’s treatments at the Salk Institute have uncovered some key mechanisms that enable an experimental drug to reverse memory loss in mouse models of the disease. The discovery not only bodes well for the possibility of clinical trials, but provides researchers with a new target to consider in the wider development of compounds to counter the degenerative effects of the condition.

The research centers on a drug called CMS121, which is a synthetic version of a chemical called fisetin that occurs naturally in fruits and vegetables. The Salk team’s previous studies concerning CMS121 have produced some very promising results, with one paper published last year describing how the drug influences age-related metabolic pathways in the brain, protecting against the type of degeneration associated with Alzheimer’s. This followed earlier studies demonstrating how fisetin can prevent memory loss in mice engineered to develop Alzheimer’s.

Work continues at Salk to understand how exactly fisetin and the synthetic variant CMS121 produces these anti-aging effects on the brain. In their latest study, the researchers again turned to mice engineered to develop Alzheimer’s, which were administered daily doses of CMS121 from the age of nine months. This is the equivalent to middle age in humans, with the mice already exhibiting learning and memory problems before the treatment began.

Three months later, the mice were subjected to memory and behavior tests alongside a control group of mice that received no treatment at all and a group of mice that were perfectly healthy. The Alzheimer’s-like mice that underwent the CMS121 treatment performed just as well as the healthy control group on the tests, but the untreated mice performed much more poorly.

In order to dig into the details of why this might be, the team analyzed levels of certain molecules in the brains of the three different groups. In doing so, they found that the mice exhibited a few key differences surrounding the brain's metabolism of fatty molecules called lipids. More specifically, in the way that lipids are degraded to produce free radical molecules that go on to cause damage to healthy cells.

The team’s analysis revealed that this process, called lipid peroxidation, was heightened in the mice with the disease that went without treatment, when compared to the two other groups. Further probing revealed that CMS121 seems to inhibit lipid peroxidation by lowering levels of a key lipid-producing molecule, called fatty acid synthetase (FASN).

This prompted the team to analyze FASN levels in brain samples of deceased Alzhiemer’s patients. These human subjects were found to have higher amounts of the FASN molecule than healthy controls of a similar age, indicating that FASN could in fact be a target with plenty of potential in the field of Alzheimer’s research.

“There has been a big struggle in the field right now to find targets to go after,” says Maher. “So, identifying a new target in an unbiased way like this is really exciting and opens lots of doors.”

These results bolster the potential of CMS121 to treat Alzheimer’s, and the team continues to work toward clinical trials to study its effectiveness in humans. But the study also opens up interesting new pathways in the field, with the researchers hopeful it can inspire other scientists to investigate compounds that target FASN and the process of lipid peroxidation.

 

 

 

Bottom top
AEOI Chief: Multilateralism in Danger by US' Destructive Policies

TEHRAN (FNA)- Head of the Atomic Energy Organization of Iran (AEOI) Ali Akbar Salehi underlined the need for the global community to stand against the US bullying, reiterating that ending Washington's destructive behavior is necessary to protect multilateralism.
Leader: Sacred Defense Showed Invading Iran Too Costly

TEHRAN (FNA)- Supreme Leader of the Islamic Revolution Ayatollah Seyed Ali Khamenei underlined that Iran's decisively victorious defense against foreign-backed forces of Iraq’s former dictator Saddam Hussein proved that invading the country is "too costly".
Official: Iran Able to Increase Oil Production to 8.5mln Barrels

TEHRAN (FNA)- A senior member of Iran’s Expediency Council (EC) underlined the country’s capability to produce 8.5mln barrels of oil.
Leaked Docs: US Branches of Deutsche Bank Suspected of Facilitating Funds to Daesh in Iraq

TEHRAN (FNA)- Leaked reports revealed that the US branches of Deutsche Bank are suspected of facilitating money transfer to Daesh (ISIL or ISIS) in Iraq at the height of the group's terror campaign.
Iranian FM: Igniters of War Not Able to End It

TEHRAN (FNA)- Iran’s Foreign Minister Mohammad Javad Zarif commemorated the Iranians' sacrifices during the 8 years of the Iraqi imposed war in 1980s, warning enemies that they may initiate war against his nation, but won't be the one who finishes it off.
Trump Mocks Journalist Shot by Rubber Bullets During George Floyd Protests, Says It Was A ‘Beautiful Sight’

TEHRAN (FNA)- US President Donald Trump described the moment police shot an MSNBC reporter with rubber bullets amid protests in May as “a beautiful sight”.
China Air Force Releases Clip Appearing to Show Mock Attack on US Airbase

TEHRAN (FNA)- China's Air Force released a video showing nuclear-capable H-6 bombers carrying out a simulated missile strike, destroying what appears to be the United States airbase on the island of Guam.
Iranian Experts Overhaul Boeing 747 Plane

TEHRAN (FNA)- Iranian experts succeeded in overhauling a 50-year-old Boeing 747 cargo plane amid harsh US sanctions against the country.
UK Scientific Adviser Warns Deaths Will Rise to Hundreds A Day If Coronavirus Continues at Current Rate

TEHRAN (FNA)- The UK could see 50,000 new coronavirus cases a day by mid-October, leading to more than 200 daily deaths, if the rate of increase in infections continues to rise at current rates, the government’s chief scientific adviser Patrick Vallance warned.
IRGC Commander: US Rotten Inwardly, Isolated Globally

TEHRAN (FNA)- Islamic Revolution Guards Corps (IRGC) Commander Major General Hossein Salami said the US has become rotten internally and isolated externally, and asked Iranian people not to be worried about American threats.
London Mayor Urged to Boycott Saudi-Hosted G20 Mayors Summit

TEHRAN (FNA)- Mainly leftwing mayors of some of the world’s biggest cities are being urged to boycott a G20 urban summit hosted by Saudi Arabia on the 2nd anniversary of the murder of the journalist Jamal Khashoggi.
Iraqi Baath Documents Reveal Pahlavi Regime’s Collaboration with Saddam in Bombing Iranian Cities

TEHRAN (FNA)- Documents left from the intelligence service of the former Baath regime in Iraq disclosed that the family members of deposed Shah of Iran supplied the ex-Iraqi dictator Saddam Hussein with military equipment and weapons that had not been sent to Iran yet to attack the Iranian cities during the 8-year imposed war (1980-1988).
Iranian Supreme Leader's Videoconference Meeting with War Veterans

TEHRAN (FNA)- Supreme Leader of the Islamic Revolution Ayatollah Seyed Ali Khamenei holds a videoconference meeting with War veterans on Monday. [PHOTOS]
Iran Air to Resume Flights to Istanbul

TEHRAN (FNA)- Iran’s main airline company Homa, known internationally as IranAir, announced on Sunday that it is going to resume flights to Istanbul after seven-months of hiatus due to the coronavirus outbreak.
Iran: Washington’s Conduct Blatant Violation of Global Rules

TEHRAN (FNA)- Iranian Judiciary Chief Seyed Ebrahim Rayeesi said the present misconduct by US is a flagrant violation of the international laws and regulations.