Joshua Taylor and Brandon Dingman, from the Wilson Police Department in Oklahoma, were charged on Thursday with second-degree murder following the death of 28-year-old Jared Lakey, Sky News reported.
In a statement, the Oklahoma State Bureau of Investigation (OSBI) said the officers had responded to a call "that involved Mr. Lakey acting in a disorderly way" shortly before midnight on July 4, 2019.
"When Lakey would not comply with commands from the officers, Taylor and Dingman used their Tasers multiple times," it added.
Court documents announced the officers used their stun guns on Lakey more than 50 times "which greatly exceeded what would have been necessary or warranted by the attendant circumstances", and was a "substantial factor" in his death.
Lakey was taken into custody but stopped breathing and became unresponsive, the OSBI announced. He was admitted to hospital and died on July 6, 2019.
The OSBI said it conducted an investigation into the circumstances that led to Lakey's death and a report was submitted to the district attorney's office.
Arrest warrants were issued for 25-year-old Taylor and Dingman, 34, on July 1, and both officers turned themselves in to the Carter County Sheriff's Office.
Both men have been released on bond, which was set at $250,000 (£200,000).
If convicted, each officer faces a punishment of 10 years to life in prison.
The charges against the officers come after widespread protests in the US and around the world in recent weeks following the death of George Floyd in police custody in Minneapolis.